Rous sarcoma virus oncogene

The road to Src. Oncogene 23 : — Transcriptional profile of Rous Sarcoma Virus transformed chicken embryo fibroblasts reveals new signaling targets of viral-src. Virology : 10— Cellular processes of v-Src transformation revealed by gene profiling of primary cells-implications for human cancer.

BMC Cancer 10 : Article Google Scholar. A novel viral oncogene with structural similarity to phospholipase C. Clin Cancer Res 16 : — Urokinase plasminogen activator system as a potential target for cancer therapy.

Future Oncol 5 : — Nucleic Acid Res 12 : — Hormonal regulation of plasminogen activator mRNA production in porcine kidney cells. Cell 32 : — Ossowski L, Reich E. Antibodies to plasminogen activator inhibit human tumor metastasis.

Cell 35 : — Patnaik A, Wills JW. In vivo interference of Rous sarcoma virus budding by cis expression of a WW domain. J Virol 76 : — Avian sarcoma virus and human immunodeficiency virus type 1 use different subsets of ESCRT proteins to facilitate budding process.

Identification of a ten-amino acid proline-rich SH3 binding site. Science : — Rous P. A Transmissible Avian Neoplasm. Sarcoma of the Common Fowl. J Exp Med 12 : — J Exp Med 13 : — Saad F, Lipton A. SRC kinase inhibition: targeting bone metastases and tumor growth in prostate and breast cancer.

Cancer Treat Rev 36 : — A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus Pgag-fps. Mol Cell Biol 6 : — Identification, validation, and clinical implementation of tumor-associated biomarkers to improve therapy concepts, survival, and quality of life of cancer patients: tasks of the Receptor and Biomarker Group of the European Organization for Research and Treatment of Cancer.

Int J Oncol 25 : — Clinical impact of the plasminogen activation system in tumor invasion and metastasis: prognostic relevance and target for therapy. Thromb Haemost 78 : — Plasminogen activator inhibitor-1 in tumor growth, angiogenesis and vascular remodeling.

Curr Pharm Des 9 : — Sudol M. Hormonal regulation of protein synthesis in cultured kidney cells. Mol Cell Endocrinol 40 : — Yes-associated protein YAP65 is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product.

Oncogene 9 : — Blacksmith of words. Letter to the Editor on the centennial of the birth of Samuel Beckett. The Danville News Pennsylvania , 16 August issue. Characterization of the mammalian YAP Yes-associated protein gene and its role in defining a novel protein module, the WW domain. Sudol M, Harvey KF. Modularity in the Hippo signaling pathway. Trends Biochem Sci 35 : — Sudol M, Reich E. Purification and characterization of a plasminogen activator secreted by a pig kidney cell line. Biochem J : — Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein.

Cell 49 : — Suzuki Y. Role of tissue-type plasminogen activator in ischemic stroke. J Pharmacol Sci : — Temin HM, Mizutani S.

Feasibility of measuring the prognostic factors uPA and PAI-1 in core needle biopsy breast cancer specimens. J Natl Cancer Inst : — The urokinase plasminogen activator system: a target for anti-cancer therapy.

Curr Cancer Drug Targets 9 : 32— An enzymatic function associated with transformation of fibroblasts by oncogenic viruses. Chick embryo fibroblast cultures transformed by avian RNA tumor viruses. J Exp Med : 85— Vogt PK. Oncogenes and the revolution in cancer research: homage to Hidesaburo Hanafusa — Genes Cancer 1 : 6— Three-dimensional structure of the tyrosine kinase c-Src. Download references.

Special thanks are to Mario Gimona for translating the publication of Fischer from German to English and for valuable comments on the text, Bethany Antos and Lee Hiltzik from the Rockefeller Archive Center for the photographs and information about Rous Centennial.

Kathy Sheridan and Peter K Vogt are thanked for valuable comments on the early version of the manuscript, and Angelika Barnekow for a fruitful collaboration and permission to mention our unpublished data. My postdoctoral mentor, the late Hidesaburo Hanafusa, is remembered with warmth. This mini-review is not meant to comprehensively discuss all relevant publications. The references are intentionally selective and the author apologizes for omission of many pertinent publications, and for the myopic focus of this article.

You can also search for this author in PubMed Google Scholar. Correspondence to M Sudol. Supplementary information accompanies the paper on the Oncogene website.

Reprints and Permissions. Sudol, M. From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management. Oncogene 30, — Download citation. Received : 26 September Revised : 17 January Accepted : 24 January Published : 07 March Issue Date : 07 July Anyone you share the following link with will be able to read this content:.

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PloS One. Immune escape of cancer cells with beta2-microglobulin loss over the course of metastatic melanoma. Resistance to checkpoint blockade therapy through inactivation of antigen presentation. Nat Commun. Impaired HLA class I antigen processing and presentation as a mechanism of acquired resistance to immune checkpoint inhibitors in lung cancer. Cancer Discov. Dual faces of IFNgamma in cancer progression: a role of PD-L1 induction in the determination of pro- and antitumor immunity.

Clin Cancer Res. The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy. J Gene Med. Viral loads correlate with upregulation of PD-L1 and worse patient prognosis in Epstein-Barr Virus-associated gastric carcinoma. Sci Immunol. Curr Top Microbiol Immunol. Tumor suppressor miRa targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia.

Cell Signal. J Clin Oncol. Integrative analysis reveals selective 9p Genomic analyses of flow-sorted Hodgkin Reed-Sternberg cells reveal complementary mechanisms of immune evasion. Blood Adv. Cancer Disco. Immunity ;— Acquired resistance to immune checkpoint inhibitors.

Old dogs, new trick: classic cancer therapies activate cGAS. Cell Res. Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Innate immune signaling and regulation in cancer immunotherapy. Download references. You can also search for this author in PubMed Google Scholar.

JJR wrote and edited the manuscript and prepared the figures and table. MKIA contributed to the section on checkpoint molecules. MP wrote and edited the manuscript.

All authors approved the final version. Correspondence to Mary Philip. Reprints and Permissions. Roetman, J. Viral and cellular oncogenes promote immune evasion. Oncogene Download citation. Received : 20 May Revised : 24 November Accepted : 01 December Published : 13 January Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.

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Change institution. Buy article Get time limited or full article access on ReadCube. References 1. Google Scholar 5. PubMed Google Scholar Scientists eventually learned that src makes a type of protein called a kinase. Kinases are enzymes — proteins that speed up chemical reactions.

This sticking-on of phosphates is called phosphorylation. Kinases help control growth and reproduction in cells, among other behaviors. Normally, they are active for a time, then the cell switches them off.

The mutant version of the src gene, found in RSV, makes a kinase that is essentially on all the time, like a gas pedal stuck to the floor.

Resh says. Getting infected with RSV is one way to acquire this mischievous oncogene. Since src was discovered, scientists have found numerous other oncogenes in cells. Many, like src , encode protein kinases. In their normal form, they are referred to as proto-oncogenes; in their mutated cancer-causing form, they are called oncogenes.

Knowing which genes and proteins are malfunctioning to cause cancer opens the door to targeted therapies directed at these bad actors. Src was the first oncogene identified and also the first tyrosine protein kinase, making it a good drug target. Chickens are also a good cancer model because their telomeres are regulated like ours.

Skip to main content Important Update to Visitor Policy. Funky Chicken Virus The rediscovery of Dr. That was really the first hint that cancer, or a tumor, could be transmitted by a microscopic, noncellular agent — what we now call a virus.

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